Title : NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway.

Pub. Date : 2022 Mar 14

PMID : 35298964






3 Functional Relationships(s)
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1 RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis. sodium arsenite caspase 3 Homo sapiens
2 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite caspase 3 Homo sapiens
3 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite caspase 3 Homo sapiens