Title : Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses.

Pub. Date : 2022 Mar 16

PMID : 35294258






1 Functional Relationships(s)
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1 IDO1 inhibition resulted in efficient blockade of the kynurenine pathway of tryptophan degradation and was accompanied by a metabolic adaptation that shunted tryptophan catabolism toward the serotonin pathway. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens