Title : The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.

Pub. Date : 2022 Jul

PMID : 35293666






1 Functional Relationships(s)
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1 This action of GTS-21 was reproduced by alpha7nAChR agonist PNU-282987, was enhanced by sitagliptin, was counteracted by Exendin(9-39), and was absent in alpha7nAChR and GLP-1R KO mice. PNU-282987 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus