Pub. Date : 2022 May
PMID : 35274449
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fingolimod ameliorates acetic acid-induced ulcerative colitis: An insight into its modulatory impact on pro/anti-inflammatory cytokines and AKT/mTOR signalling. | Fingolimod Hydrochloride | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | BACKGROUND: Because of the approved immunomodulatory activities of fingolimod, the current study aimed at studying the curative potential of fingolimod against experimentally induced ulcerative colitis (UC) via modulating pro/anti-inflammatory cytokines release and AKT/mTOR signalling. | Fingolimod Hydrochloride | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | In addition, fingolimod decreased the expressions of AKT and mTOR compared to the UC group. | Fingolimod Hydrochloride | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | CONCLUSION: Fingolimod attenuated acetic acid-induced UC through its immunomodulatory effect by shifting the balance to favour anti-inflammatory cytokine production rather than pro-inflammatory cytokines and modulating the AKT/mTOR signalling. | Fingolimod Hydrochloride | AKT serine/threonine kinase 1 | Rattus norvegicus |