Title : Dipeptide metalloendoprotease substrates are glucose transport inhibitors and membrane structure perturbants.

Pub. Date : 1986 Jul 1

PMID : 3527260






2 Functional Relationships(s)
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1 We find that synthetic dipeptides which are metalloendoprotease substrates rapidly and reversibly inhibit insulin-activated glucose oxidation in a dose-dependent manner but exhibit essentially no effect on basal levels. Dipeptides insulin Homo sapiens
2 That is, the dipeptide substrates inhibit insulin-activated glucose uptake to a greater extent than basal transport, and they do so even when vesicle translocation and fusion have already taken place as in ATP-depleted cells and isolated vesicles. Dipeptides insulin Homo sapiens