Title : The α7 nAChR allosteric modulator PNU-120596 amends neuroinflammatory and motor consequences of parkinsonism in rats: Role of JAK2/NF-κB/GSk3β/ TNF-α pathway.

Pub. Date : 2022 Apr

PMID : 35272136






1 Functional Relationships(s)
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1 This is the first study to reveal the positive effects of PNU-120596 on motor derangements of PD via JAK2/NF-kappaB/GSk3beta/ TNF-alpha neuroinflammatory pathways, which could offer a potential therapeutic strategy for PD. 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea Janus kinase 2 Rattus norvegicus