Title : Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway.

Pub. Date : 2022 Mar 5

PMID : 35270009






2 Functional Relationships(s)
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1 Furthermore, pretreatment of cells with SP600125 (JNK inhibitor; 10 muM) or NAC (1 mM) or transfection with JNK-specific siRNA obviously attenuated the MeHg-induced JNK phosphorylation, CHOP and XBP-1 protein expression, apoptotic events, and insulin secretion dysfunction. Acetylcysteine mitogen-activated protein kinase 8 Rattus norvegicus
2 NAC significantly inhibited MeHg-activated JNK signaling, but SP600125 could not effectively reduce MeHg-induced ROS generation. Acetylcysteine mitogen-activated protein kinase 8 Rattus norvegicus