Title : Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In Vivo.

Pub. Date : 2022 Mar 24

PMID : 35238566






3 Functional Relationships(s)
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1 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
2 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
3 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens