Pub. Date : 2022 Feb 22
PMID : 35224365
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 2 | The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 3 | The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 4 | The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 5 | The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 6 | Recently, we hypothesized that 5-FU-resistant colorectal cancer (CRC) cells have increased levels of TS protein relative to 5-FU-sensitive CRC cells and use a fraction of their TS to trap FdUMP, which results in resistance to 5-FU. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 7 | Recently, we hypothesized that 5-FU-resistant colorectal cancer (CRC) cells have increased levels of TS protein relative to 5-FU-sensitive CRC cells and use a fraction of their TS to trap FdUMP, which results in resistance to 5-FU. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 8 | Recently, we hypothesized that 5-FU-resistant colorectal cancer (CRC) cells have increased levels of TS protein relative to 5-FU-sensitive CRC cells and use a fraction of their TS to trap FdUMP, which results in resistance to 5-FU. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 9 | In this study, we analyzed the difference between the regulation of the balance of the free, active form of TS and the inactive FdUMP-TS form in 5-FU-resistant HCT116 cells and parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 10 | In this study, we analyzed the difference between the regulation of the balance of the free, active form of TS and the inactive FdUMP-TS form in 5-FU-resistant HCT116 cells and parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 11 | Silencing of TYMS, the gene that encodes TS, resulted in greater enhancement of the anticancer effect of 5-FU in the 5-FU-resistant HCT116RF10 cells than in the parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 12 | Silencing of TYMS, the gene that encodes TS, resulted in greater enhancement of the anticancer effect of 5-FU in the 5-FU-resistant HCT116RF10 cells than in the parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 13 | Silencing of TYMS, the gene that encodes TS, resulted in greater enhancement of the anticancer effect of 5-FU in the 5-FU-resistant HCT116RF10 cells than in the parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 14 | Silencing of TYMS, the gene that encodes TS, resulted in greater enhancement of the anticancer effect of 5-FU in the 5-FU-resistant HCT116RF10 cells than in the parental HCT116 cells. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 15 | Our observations suggest that the regulation of the balance between the storage of the active TS form and the accumulation of FdUMP-TS is responsible for direct resistance to 5-FU. | Fluorouracil | thymidylate synthetase | Homo sapiens |
| 16 | Our observations suggest that the regulation of the balance between the storage of the active TS form and the accumulation of FdUMP-TS is responsible for direct resistance to 5-FU. | Fluorouracil | thymidylate synthetase | Homo sapiens |