Title : Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway.

Pub. Date : 2022 Jan 24

PMID : 35200626






2 Functional Relationships(s)
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1 Importantly, COS inhibited the activation of the NF-kappaB signaling pathway via activating PPARgamma and SIRT1, thus reducing the production of NO and IL-6. carbonyl sulfide peroxisome proliferator activated receptor gamma Mus musculus
2 The antagonist of PPARgamma could abolish the anti-inflammatory effects of COS in LPS-treated cells. carbonyl sulfide peroxisome proliferator activated receptor gamma Mus musculus