Title : Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.

Pub. Date : 2022

PMID : 35198063






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that saturated free fatty acids (SFA), which are increased in obesity, together with S100A9 induce TLR4 and inflammasome-dependent IL-1beta release in macrophages which in turn amplifies S100A9 expression initiating a vicious cycle of sustained S100A9 overexpression in skin inflammation in obesity. Fatty Acids toll-like receptor 4 Mus musculus