Pub. Date : 2022 Feb 24
PMID : 35196878
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diacerein treatment mitigated the cartilage damage and significantly inhibited the DNMT1/3a upregulations, the PPARgamma promoter hypermethylation and the PPARgamma loss, and effectively corrected the adverse expression of antioxidant enzymes and inflammatory cytokines. | diacerein | DNA methyltransferase (cytosine-5) 1 | Mus musculus |
| 2 | In cultured chondrocytes, diacerein reduced the IL-1beta-induced PPARgamma suppression and the abnormal expression of its downstream antioxidant enzymes in a gain of DNMT and PPARgamma inhibition-sensitive manner, and in PPARgamma knockout mice, the anti-OA effects of diacerein were significantly reduced. | diacerein | DNA methyltransferase (cytosine-5) 1 | Mus musculus |
| 3 | INNOVATION: Our work reveals a novel anti-OA pharmacological property of diacerein, and identifies the aberrant DNMT elevations and the resultant PPARgamma suppression as an important epigenetic pathway that mediates diacerein"s anti-OA activities. | diacerein | DNA methyltransferase (cytosine-5) 1 | Mus musculus |