Pub. Date : 2022
PMID : 35196318
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The current study investigated the effect of TGF-beta1 on receptor activator of nuclear factor kappa-B ligand (RANKL) expression in stromal cells induced by 1alpha,25(OH)2D3 (D3) and dexamethasone (Dex). | Cholecalciferol | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 2 | The current study investigated the effect of TGF-beta1 on receptor activator of nuclear factor kappa-B ligand (RANKL) expression in stromal cells induced by 1alpha,25(OH)2D3 (D3) and dexamethasone (Dex). | Cholecalciferol | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 3 | TGF-beta1 downregulated the expression of RANKL induced by D3 and Dex in mouse bone marrow stromal lineage, ST2 cells. | Cholecalciferol | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 4 | These results indicated that TGF-beta1 downregulates RANKL expression and the osteoclast-supporting activity of osteoblasts/stromal cells induced by D3 and Dex through the degradation of the RXR-alpha protein mediated by ubiquitin-proteasome system. | Cholecalciferol | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |