CPRiL

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

Enables identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of secretion by cell. Acts upstream of or within several processes, including cellular response to cytokine stimulus; mammary gland development; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be active in extracellular space. Is expressed in bone; genitourinary system; hemolymphoid system; incisor; and rib. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11). [provided by Alliance of Genome Resources, Jun 2025]

• tumor necrosis factor ligand superfamily member 11
• OPG ligand
• TNF-related activation-induced cytokine
osteoclast differentiation factor
osteoprotegerin ligand
receptor activator of NF-kappaB ligand
receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor-related activation-induced cytokine
Ly109l
ODF
OPGL
RANKL
Trance