Protein Name tumor necrosis factor (ligand) superfamily, member 11
Organism Mus musculus
Gene ID 21943
Gene Symbol

Tnfsf11

UniProt O35235 (TNF11_MOUSE)
Relationships Total Number of functionally related compound(s) : 974
Total Number of Articles : 1272
Description

tumor necrosis factor (ligand) superfamily, member 11

Gene Summary

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tumor necrosis factor ligand superfamily member 11
  • OPG ligand
  • TNF-related activation-induced cytokine
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Properties