Title : Prenatal exposure to triphenyl phosphate activated PPARĪ³ in placental trophoblasts and impaired pregnancy outcomes.

Pub. Date : 2022 May 15

PMID : 35192884






2 Functional Relationships(s)
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1 To further confirm the role of PPARgamma in TPhP mediated placental toxicity, pregnant mice were orally exposed to TPhP (1 mg/kg) or TPhP (1 mg/kg) + GW9662 (PPARgamma inhibitor, 2 mg/kg) from E0 until delivery. 2-chloro-5-nitrobenzanilide peroxisome proliferator activated receptor gamma Mus musculus
2 The results showed that GW9662 could ameliorate the effect of TPhP on placental lipid accumulation, ERS and cell apoptosis, suggesting that PPARgamma mediated the placental toxicity of TPhP. 2-chloro-5-nitrobenzanilide peroxisome proliferator activated receptor gamma Mus musculus