Title : Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.

Pub. Date : 2022 Apr

PMID : 35189109






1 Functional Relationships(s)
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1 Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria. Superoxides inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens