Title : Glibenclamide Alleviates LPS-Induced Acute Lung Injury through NLRP3 Inflammasome Signaling Pathway.

Pub. Date : 2022

PMID : 35185385






2 Functional Relationships(s)
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1 Meanwhile, the increased proteins of NLRP3 and Caspase-1/p20 after LPS instillation in lungs were downregulated by glibenclamide. Glyburide caspase 1 Mus musculus
2 In conclusion, glibenclamide alleviates the development of LPS-induced ALI in a mouse model via inhibiting the NLRP3/Caspase-1/IL-1beta signaling pathway, which might provide a new strategy for the treatment of LPS-induced ALI. Glyburide caspase 1 Mus musculus