Protein Name caspase 1
Organism Mus musculus
Gene ID 12362
Gene Symbol


UniProt P29452 (CASP1_MOUSE)
Relationships Total Number of functionally related compound(s) : 685
Total Number of Articles : 953

caspase 1

Gene Summary

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

  • caspase-1
  • CASP-1
  • IL-1 beta-converting enzyme
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