Title : The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression.

Pub. Date : 2022 Feb

PMID : 35184402






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Gene knockdown in THP1-derived TAMs was performed with lentivirus, and the impact of THP1-derived TAMs on invasion and metastasis ability of PDAC cells were investigated with in vitro and in vivo functional assays. tams GLI family zinc finger 2 Homo sapiens
2 Knockdown of CTCF in THP1-derived TAMs led to the down-regulation of specific markers for M2-polarised TAMs, including CD206 and CD163. tams GLI family zinc finger 2 Homo sapiens
3 Knockdown of CTCF in THP1-derived TAMs led to the down-regulation of specific markers for M2-polarised TAMs, including CD206 and CD163. tams GLI family zinc finger 2 Homo sapiens
4 Knockdown of PACERR exhibited a similar phenotype as observed in CTCF knockdown THP1-derived TAMs. tams GLI family zinc finger 2 Homo sapiens