Protein Name GLI family zinc finger 2
Organism Homo sapiens
Gene ID 2736
Gene Symbol


UniProt P10070 (GLI2_HUMAN), Q1PSW9 (Q1PSW9_HUMAN), Q59FV5 (Q59FV5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1670
Total Number of Articles : 2443

GLI family zinc finger 2

Gene Summary

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

  • zinc finger protein GLI2
  • GLI family zinc finger protein 2
  • GLI-Kruppel family member GLI2
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