Title : Discovery of Anticancer Hybrid Molecules by Supervised Machine Learning Models and in Vitro Validation in Drug Resistant Chronic Myeloid Leukemia Cells.

Pub. Date : 2022 Feb 28

PMID : 35172577






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1 Here, we report the design of unique hybrid molecules by combining the two pharmacophores of clinically approved BCR-ABL inhibitor (ponatinib) and HDAC inhibitor (vorinostat) and results of in vitro studies in drug-resistant CML cells. ponatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens