Pub. Date : 2022 Feb 10
PMID : 35169791
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Their modulators with therapeutic potential include 1PBC, a potent inhibitor with anti-tumoral properties, and the FDA-approved drug niclosamide that targets TMEM16F to inhibit syncytia formation induced by SARS-CoV-2 infection. | Niclosamide | anoctamin 6 | Homo sapiens |
| 2 | Here, we report cryo-EM structures of TMEM16F associated with 1PBC and niclosamide, revealing that both molecules bind the same drug binding pocket. | Niclosamide | anoctamin 6 | Homo sapiens |