Pub. Date : 2022 Jan 25
PMID : 35163281
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin was effective in protecting B16F10 cells from alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis and tyrosinase activity. | 7,3'-dihydroxy-4'-methoxyisoflavone | tyrosinase | Mus musculus |
| 2 | This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells. | 7,3'-dihydroxy-4'-methoxyisoflavone | tyrosinase | Mus musculus |
| 3 | The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways. | 7,3'-dihydroxy-4'-methoxyisoflavone | tyrosinase | Mus musculus |