Title : NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination, and seizure threshold.

Pub. Date : 2022 Feb 8

PMID : 35136953






1 Functional Relationships(s)
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1 Nprl3 knockout in vitro caused mTOR pathway hyperactivation, cell soma enlargement, and the formation of cellular aggregates seen in time-lapse videos that were prevented with the mTOR inhibitors rapamycin or torin1. Sirolimus mechanistic target of rapamycin kinase Mus musculus