Title : Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-κB and p38 MAPK pathway.

Pub. Date : 2022 Jan 29

PMID : 35121391






3 Functional Relationships(s)
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1 Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-kappaB and p38 MAPK pathway. schizandrin B nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 The in vitro and in vivo assays indicated that schisandrin B ameliorated CCl4-induced liver fibrosis through suppressing NF-kappaB and p38 MAPK pathway in Kupffer cells by targeting CB2 receptor CONCLUSION: Schisandrin B targets CB2 receptor to inhibit Kupffer cell polarization by downregulating the NF-kappaB and p38 MAPK signaling pathways for ameliorating liver fibrosis. schizandrin B nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 The in vitro and in vivo assays indicated that schisandrin B ameliorated CCl4-induced liver fibrosis through suppressing NF-kappaB and p38 MAPK pathway in Kupffer cells by targeting CB2 receptor CONCLUSION: Schisandrin B targets CB2 receptor to inhibit Kupffer cell polarization by downregulating the NF-kappaB and p38 MAPK signaling pathways for ameliorating liver fibrosis. schizandrin B nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus