Pub. Date : 2022 Mar
PMID : 35104501
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The 1H-15N heteronuclear single quantum correlation (HSQC) and saturation-transfer difference (STD) NMR data suggest that calcium-free atorvastatin exerts its effect through interaction with the 16KLVF19 binding site on the Abeta peptide via its aromatic rings as well as hydroxyl and methyl groups. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 2 | Overall, the aggregation modulatory effect of atorvastatin on Abeta varies by calcium concentration, an ion that exhibits large spatiotemporal variation within the brain tissue and may also influence the anti-aggregation effect of other small molecules previously reported. | Calcium | amyloid beta precursor protein | Homo sapiens |