Pub. Date : 2022 Jan-Dec
PMID : 35099304
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | The aim of the current study was to investigate the effects of seven allelic variants on the ability of CYP3A5 to metabolize sorafenib in vitro and further explore the impacts of CYP3A5 polymorphism on the proliferation and apoptosis of hepatocellular carcinoma cell line (HepG2) induced by sorafenib. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | CONCLUSION: Our results suggest that CYP3A5 polymorphism influences sorafenib metabolism and pharmacotherapeutic effect in hepatic carcinomas. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |