Title : Melatonin Improves the Resistance of Oxidative Stress-Induced Cellular Senescence in Osteoporotic Bone Marrow Mesenchymal Stem Cells.

Pub. Date : 2022

PMID : 35087617






1 Functional Relationships(s)
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1 Treatment with either SIRT1 inhibitor (sirtinol) or melatonin receptor antagonists (luzindole and 4-P-PDOT) eliminated melatonin protective effects, thus indicating its potential in preventing stem cell senescence via SIRT1 activation through the melatonin membrane receptors. 4-phenyl-2-propionamidotetraline sirtuin 1 Rattus norvegicus