Protein Name sirtuin 1
Organism Rattus norvegicus
Gene ID 309757
Gene Symbol


UniProt -
Relationships Total Number of functionally related compound(s) : 595
Total Number of Articles : 1070

sirtuin 1

Gene Summary

Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in cytosol; growth cone; and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); impotence; non-alcoholic fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Apr 2022]

  • NAD-dependent protein deacetylase sirtuin-1
  • NAD-dependent deacetylase sirtuin-1
  • NAD-dependent protein deacylase sirtuin-1
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