Title : Alpha-synuclein/MPP+ mediated activation of NLRP3 inflammasome through microtubule-driven mitochondrial perinuclear transport.

Pub. Date : 2022 Feb 26

PMID : 35085893






1 Functional Relationships(s)
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1 The co-treatment of alpha-syn/MPP+ can cause aberrant mitochondrial homeostasis to diminish the concentration of the coenzyme nicotinamide adenine dinucleotide (NAD+), mediate accumulation of ac-alpha-tubulin, and induce mitochondrial perinuclear aggregation, navigating the co-localization of NLRP3 and apoptosis-associated speck-like protein containing a CARD domain (ASC). NAD NLR family, pyrin domain containing 3 Mus musculus