Title : Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers.

Pub. Date : 2022 Jan 26

PMID : 35083640






3 Functional Relationships(s)
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1 The fetal-to-maternal plasma concentration ratio of digoxin was only marginally affected in Mdr1a-/-/Mdr1b-/- mice, while that of paclitaxel showed a several-fold increase. Digoxin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus
2 The impact per single MDR1 molecule on the fetal distribution of digoxin was calculated to be much lower than that on the brain distribution, but this was not the case for paclitaxel. Digoxin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus
3 CONCLUSION: Our findings indicate that murine placental MDR1 has a minimal influence on the fetal concentration of certain substrates, such as digoxin, due to bypass transfer, probably via connexin26 gap junctions. Digoxin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus