Title : Protein phosphatase 2A catalytic subunit β suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling.

Pub. Date : 2022 Jan 24

PMID : 35068054






1 Functional Relationships(s)
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1 Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF). Ionomycin interleukin 2 Mus musculus