Title : Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice.

Pub. Date : 2022 May 24

PMID : 35061889






5 Functional Relationships(s)
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1 Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
2 Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
3 Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
4 Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
5 In iron-deprived mice, oral intragastric administration of the 4AA formulation increased DMT1 protein abundance on the enterocyte BBM (by ~1.5-fold; p<0.05). Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus