Title : The inhibition of Panc1 cancer cells invasion by hAMSCs secretome through suppression of tyrosine phosphorylation of SGK223 (at Y411 site), c-Src (at Y416, Y530 sites), AKT activity, and JAK1/Stat3 signaling.

Pub. Date : 2022 Jan 20

PMID : 35059869






2 Functional Relationships(s)
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Protein Name
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1 Tyrosine phosphorylated SGK223 at Y411 enables to interact with CSK resulting up regulation of c-Src activity and promotion of the cell migration. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Herein, we employed a co-culture system to clarify the effects of hAMSCs secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens