Title : Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells.

Pub. Date : 2022 Jan 20

PMID : 35058496






2 Functional Relationships(s)
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1 Treatment of the ZIKV-infected cells with dexamethasone (150 microM) reduced HMGB1 extracellular release in a dose-dependent manner, with a maximum reduction of 71 +- 5.84% (P < 0.01). Dexamethasone high mobility group box 1 Homo sapiens
2 These results suggest that translocation of HMGB1 occurred during ZIKV infection and inhibition of the translocation by dexamethasone coincided with a reduction in ZIKV replication. Dexamethasone high mobility group box 1 Homo sapiens