Title : Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject 'cold' tumors.

Pub. Date : 2022 Jan

PMID : 35058324






1 Functional Relationships(s)
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1 CONCLUSION: Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized alphaCTLA-4 as a highly effective and safe strategy to target CTLA-4. treg cytotoxic T-lymphocyte-associated protein 4 Mus musculus