PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35058324-13 2022 CONCLUSION: Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized alphaCTLA-4 as a highly effective and safe strategy to target CTLA-4. treg 89-93 cytotoxic T-lymphocyte-associated protein 4 Mus musculus 215-221