Title : Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.

Pub. Date : 2022 Jan 12

PMID : 35056795






1 Functional Relationships(s)
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1 This study also investigated the role of p38 and NF-kappaB in cell signaling events and found that SB203580 (an inhibitor of p38) markedly reduced p38, IKK, and p65 phosphorylation and reversed IkappaBalpha degradation as well as p65 activation in a confocal microscope, whereas BAY11-7082 had no effects in p38 phosphorylation. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens