Title : Bisphenol S Impairs Invasion and Proliferation of Extravillous Trophoblasts Cells by Interfering with Epidermal Growth Factor Receptor Signaling.

Pub. Date : 2022 Jan 8

PMID : 35054855






5 Functional Relationships(s)
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1 We hypothesized that BPS would impair EGF-mediated invasion and proliferation in EVTs. bis(4-hydroxyphenyl)sulfone epidermal growth factor Homo sapiens
2 We demonstrated that BPS blocked EGF-induced phosphorylation of EGFR by acting as a competitive antagonist to EGFR. bis(4-hydroxyphenyl)sulfone epidermal growth factor Homo sapiens
3 Transwell assay and a three-dimensional microfluidic chip invasion assay revealed that BPS exposure can block EGF-mediated cell invasion. bis(4-hydroxyphenyl)sulfone epidermal growth factor Homo sapiens
4 BPS also blocked EGF-mediated proliferation and endovascular differentiation. bis(4-hydroxyphenyl)sulfone epidermal growth factor Homo sapiens
5 In conclusion, BPS can prevent EGF-mediated EVT proliferation and invasion through EGFR antagonism. bis(4-hydroxyphenyl)sulfone epidermal growth factor Homo sapiens