Title : The Dual Role of the β2-Adrenoreceptor in the Modulation of IL-17 and IFN-γ Production by T Cells in Multiple Sclerosis.

Pub. Date : 2022 Jan 8

PMID : 35054851






4 Functional Relationships(s)
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1 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine adrenoceptor beta 2 Homo sapiens
2 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine adrenoceptor beta 2 Homo sapiens
3 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine adrenoceptor beta 2 Homo sapiens
4 The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation. Norepinephrine adrenoceptor beta 2 Homo sapiens