Title : Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation.

Pub. Date : 2022 May 4

PMID : 35046108






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1 In summary, our data revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARalpha. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens