Pub. Date : 2022 Mar 1
PMID : 35038735
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Wild type (WT) mice, TRbeta knockout mice (TRbeta KO), TRbeta mutant mice with either specifically abrogated DNA-binding (TRbeta GS) or abrogated direct PI3K activation (TRbeta 147F) were treated with T3 for 6h or 7 days. | Triiodothyronine | thyroid hormone receptor beta | Mus musculus |
| 2 | RESULTS: T3 induced hepatocyte proliferation with an increased number of Ki67-positive cells in WT and TRbeta 147F mice (9.2+-6.5% and 10.1+-2.9%) compared to TRbeta KO and TRbeta GS mice (1.2+-1.1% and 1.5+-0.9%). | Triiodothyronine | thyroid hormone receptor beta | Mus musculus |
| 3 | Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed. | Triiodothyronine | thyroid hormone receptor beta | Mus musculus |