PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35038735-5 2022 METHODS: Wild type (WT) mice, TRbeta knockout mice (TRbeta KO), TRbeta mutant mice with either specifically abrogated DNA-binding (TRbeta GS) or abrogated direct PI3K activation (TRbeta 147F) were treated with T3 for 6h or 7 days. Triiodothyronine 210-212 thyroid hormone receptor beta Mus musculus 64-70 35038735-9 2022 RESULTS: T3 induced hepatocyte proliferation with an increased number of Ki67-positive cells in WT and TRbeta 147F mice (9.2+-6.5% and 10.1+-2.9%) compared to TRbeta KO and TRbeta GS mice (1.2+-1.1% and 1.5+-0.9%). Triiodothyronine 9-11 thyroid hormone receptor beta Mus musculus 103-109 35038735-10 2022 Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed. Triiodothyronine 178-180 thyroid hormone receptor beta Mus musculus 196-202