Title : Prooxidative inhibition against NF-κB-mediated inflammation by pharmacological vitamin C.

Pub. Date : 2022 Feb 20

PMID : 35038551






3 Functional Relationships(s)
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1 It was found that VC and its two-electron oxidative product, dehydroascorbate (DHA) constructs an efficient redox cycle with the aid of intracellular glutathione and copper ions, thereby facilitating the generation of reactive oxygen species (ROS) and the ROS-dependent inhibition against the NF-kappaB-mediated inflammation. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 It was found that VC and its two-electron oxidative product, dehydroascorbate (DHA) constructs an efficient redox cycle with the aid of intracellular glutathione and copper ions, thereby facilitating the generation of reactive oxygen species (ROS) and the ROS-dependent inhibition against the NF-kappaB-mediated inflammation. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 It was found that VC and its two-electron oxidative product, dehydroascorbate (DHA) constructs an efficient redox cycle with the aid of intracellular glutathione and copper ions, thereby facilitating the generation of reactive oxygen species (ROS) and the ROS-dependent inhibition against the NF-kappaB-mediated inflammation. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus