Pub. Date : 2022
PMID : 35035665
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1alpha/PDK1 Axis. | celastrol | hypoxia inducible factor 1, alpha subunit | Mus musculus |
| 2 | Moreover, celastrol inhibited the I/R-induced upregulation of HIF-1alpha and PDK1. | celastrol | hypoxia inducible factor 1, alpha subunit | Mus musculus |
| 3 | Overexpression of HIF-1alpha by DMOG reversed the protective effect of celastrol on cerebral I/R injury and blocked celastrol-induced suppression of glycolysis. | celastrol | hypoxia inducible factor 1, alpha subunit | Mus musculus |
| 4 | Overexpression of HIF-1alpha by DMOG reversed the protective effect of celastrol on cerebral I/R injury and blocked celastrol-induced suppression of glycolysis. | celastrol | hypoxia inducible factor 1, alpha subunit | Mus musculus |
| 5 | Taken together, these results suggested that celastrol protected against cerebral I/R injury through inhibiting glycolysis via the HIF-1alpha/PDK1 axis. | celastrol | hypoxia inducible factor 1, alpha subunit | Mus musculus |