Pub. Date : 2022 Jan 12
PMID : 35022331
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TIMP-2 regulates 5-Fu resistance via the ERK/MAPK signaling pathway in colorectal cancer. | Fluorouracil | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We established an autocrine mechanism through which elevated TIMP-2 protein levels sustained colorectal cancer cell resistance to 5-Fu by constitutively activating the ERK/MAPK signaling pathway. | Fluorouracil | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Inhibition of TIMP-2 using an anti-TIMP-2 antibody or ERK/MAPK inhibition by U0126 suppressed TIMP-2 mediated 5-Fu-resistance in CRC patients. | Fluorouracil | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In conclusion, a novel TIMP-2-ERK/MAPK mediated 5-Fu resistance mechanism is involved in colorectal cancer. | Fluorouracil | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Therefore, targeting TIMP-2 or ERK/MAPK may provide a new strategy to overcome 5-Fu resistance in colorectal cancer chemotherapy. | Fluorouracil | mitogen-activated protein kinase 1 | Homo sapiens |