Title : Charge Matters: Mutations in Omicron Variant Favor Binding to Cells.

Pub. Date : 2022 Mar 18

PMID : 35020256






1 Functional Relationships(s)
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1 We propose based on a chemical rational that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge-charge interactions. Heparitin Sulfate surface glycoprotein Severe acute respiratory syndrome coronavirus 2