PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35020256-3 2022 We propose based on a chemical rational that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge-charge interactions. Heparitin Sulfate 243-258 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 129-134