Title : The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.

Pub. Date : 2022 Jan 10

PMID : 35013382






1 Functional Relationships(s)
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1 Further examination of the mechanisms behind these observations showed that JTE-013, at concentrations frequently used in the literature to target S1P2/4, inhibits several sphingolipid metabolic enzymes, including dihydroceramide desaturase 1 and both sphingosine kinases. Sphingolipids delta 4-desaturase, sphingolipid 1 Homo sapiens