Pub. Date : 2022 Jan 8
PMID : 34998404
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | ROS/PI3K/Akt and Wnt/beta-catenin signalings activate HIF-1alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. | Fluorouracil | catenin beta 1 | Homo sapiens |
2 | Upregulation of HIF-1alpha in 5-FU-resistant CRC occurred through non-oxygen-dependent mechanisms of reactive oxygen species-mediated activation of PI3K/Akt signaling and aberrant activation of beta-catenin in the nucleus. | Fluorouracil | catenin beta 1 | Homo sapiens |